If you have a pretty regular menstrual cycle, you know exactly when your body is telling you that your period is close. Pre-menstrual syndrome (PMS) can present itself in many ways from increased anxiety to changes in appetite. But if you have eczema, you might also notice an eczema flare before your period. “Your eczema sometimes can fluctuate with your hormone levels,” says Marisa Garshick, MD, a board-certified dermatologist in New York City. “We know that week before your period, when your estrogen level is lower, you may experience more dryness of the skin. And we know that when the skin is dry, it can predispose to a flare-up of eczema. We don’t warn patients about this but if somebody said they it, the rationale is there.” The available research on eczema flares in the week before a period is…
A Stem Cell Secretome Treatment Improves Measures of Health in Old Mice
Read More at Fight Aging! The stem cell therapy industry is evolving. There are a few reasons for this. Firstly, cells remain hard to work with as a basis for therapy, and the level of standardization expected by regulators is very challenging to achieve, even for companies with very deep pockets. In the wilder world of stem cell therapies obtained via medical tourism, outcomes vary broadly from clinic to clinic and patient to patient for reasons that remain unclear. Secondly, stem cell transplantation produces benefits to aged patients primarily via the signaling produced by transplanted cells in a short time prior their destruction, rather than through any other activity of those cells. Given these points, there is a slow shift away from using cells and towards the use of cell products such as harvested extracellular vesicles or, as in today’s…
IGF1 Gene Therapy as a Neuroprotective Treatment, Slowing Female Reproductive Aging
Read More at Fight Aging! Researchers here describe an interesting approach to slowing aspects of neurodegeneration that contribute to, among other things, female reproductive aging. That is the focus of this paper, but numerous other aspects of the aging brain are also involved. IGF1 is well studied in the context of aging, and manipulation of the signaling pathways linking insulin, IGF1, and growth hormone has been shown to extend life span in a number of species. Where we can make direct comparisons between mice and humans, such as between growth hormone receptor knockout mice and humans with Laron syndrome, the effects are nowhere near as large. Suppression of growth hormone signaling can extend life by 70% or so in mice, but Laron syndrome doesn’t appear to make humans live meaningfully longer. Many approaches to slowing aging have much larger effects…
Successful Treatment of Aging is a Goal of Great Importance to Public Health
Read More at Fight Aging! Why has the tone of writing by ethicists on the topic of treating aging as a medical condition, with consequent extension of health human life span, shifted from from hostility to endorsement over the last twenty years? One possibility is that while a technological capability is thought to be a far future possibility, or unattainable, only those with an ax to grind will talk about it. The years since the turn of the century have seen tremendous progress towards implementing therapies capable of addressing mechanisms of aging, and in lockstep with that the scientific community, and a small but sizable fraction of the public at large, have come to understand that rejuvenation and slowing of aging are viable near future goals. Some of those people are ethicists lacking an ax to grind, and some of…
Bleeding After Sex: Causes & Treatment
Read More at Sexual Post Archive – Ben’s Natural Health Bleeding after sex is an unwelcome occurrence and a source of stress and frustration for people who experience it. When that happens, people automatically generate tons of scenarios in their heads. But what is actually going on? Find out below. In this post, you’ll learn more about bleeding after sex, why it happens, and what to do about it. What is bleeding after sex? The term postcoital bleeding is used to describe cases of genital bleeding after sexual intercourse. In the medical community, this term usually applies to women. But women aren’t the only ones who can experience bleeding after sex. While it’s not a standalone disease or condition, bleeding after sexual intercourse can be a symptom of some health problems. You shouldn’t ignore it, especially if bleeding is persistent…
Loss Of Ejaculatory Sensation: Causes & Treatment
Read More at Sexual Post Archive – Ben’s Natural Health Ejaculation and orgasm are important aspects of a man’s sexual function. It is the final step in the sexual response cycle. However, ejaculation can be very difficult for some men to achieve, especially if they have a medical condition that affects their ability to do so. In some cases, men can feel no orgasm or have a painful orgasm instead of pleasure. These problems can affect sexual behavior profoundly and trigger strong emotional responses. In this article, we’re going to cover the basics you need to know about anorgasmia, which is basically a loss of ejaculatory sensation. After reading, you will be able to identify this condition and learn about its causes, treatment, and more. What is a loss of ejaculatory sensation? Loss of ejaculatory sensation is a male orgasmic…
Burning After Sex: Causes, Treatment, and Prevention
Read More at Sexual Post Archive – Ben’s Natural Health Sex should be pleasurable, enjoyable, and fun. But it’s not always that simple. Some people have a burning feeling, which makes intimacy downright taxing. At some point, the pubic region develops stinging or burning after sex. All of that discomfort can make your mind come up with the worst-case scenarios. The truth is many things can cause penile and vaginal burning after sex. And most of them are harmless. To put your mind at ease, we compiled a practical guideline on pain after sex that can answer all your queries, including ways to treat and soothe the pain. What is burning after sex? The painful burning after sex is a type of dyspareunia. Dyspareunia is genital pain that people can develop during, before, or after sex. The uncomfortable irritation and…
Senolytics, a Promising New Field of Medicine in the Treatment of Aging
Read More at Fight Aging! It is becoming harder for the world at large to ignore the field of senolytics, the large number of research groups and companies working towards therapies that clear a fraction of senescent cells from aged tissues. Senescent cells accumulate in later life, likely because the immune system becomes less able to remove them promptly. Lingering senescent cells actively disrupt normal tissue function and provoke chronic inflammation, thus contributing to age-related degeneration. Scores of mouse studies conducted over the last decade demonstrate that senolytic treatments produce rapid, reliable reversal of many age-related conditions and extension of healthy life span. Most interestingly, the best of the early senolytic treatments, the dasatinib and quercetin combination, is cheap, readily available, and in human clinical trials with promising initial results. The opening decades of the 21st century are the start…
Inguinal Hernia: Symptoms, Causes, Treatment
Read More at Sexual Post Archive – Ben’s Natural Health The term hernia refers to the cases when internal parts of the body push through a muscle weakness or a tissue wall that surrounds it. This leads to the formation of a bulge. Sometimes hernias are painful and have a major impact on quality of life. There are many types of hernia, but inguinal hernia is the most common. Learn more about it below. What is an inguinal hernia? Inguinal hernia is the most common type of hernia, and it occurs in the abdomen, i.e., near the groin. It is the bulging of the abdomen content through a weak spot in the lower portion of the abdominal wall. This type of hernia usually contains a fat part of the small intestine, but in women, it may contain an ovary. Yes,…
The Popular Press May Be Improving in Coverage of the Treatment of Aging
Read More at Fight Aging! These days, articles in the popular, non-scientific media on the topic of treating aging as a medical condition tend towards being something other than terrible. This is a considerable improvement over the state of affairs a decade ago, and night and day in comparison to the press attitudes towards aging research in the early years of this century. There is always room for improvement, and journalists are near always ill-informed about near everything they commit to paper, but nonetheless the tone is heading in the right direction: that the treatment of aging is a project, it is underway, there are many competing approaches and opinions, and, given the importance of the resulting therapies to all of our lives, this part of the scientific endeavor should not be ignored. For all the advances in medical technology…
Cellular Senesence, a Key Target in the Treatment of Aging
Read More at Fight Aging! Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system. Later in life, this balance between creation and destruction shifts, however, particularly because the immune system becomes less capable. As a result senescent cells begin to accumulate in tissues throughout the body. While the absolute numbers of senescence cells do not…
A Short Commentary on Why We Advocate for the Treatment of Aging
Read More at Fight Aging! Recently, I had the occasion to make one of my very infrequent trips to the emergency room. As always the case to date, I get to walk out afterwards, after a very long period of hurry up and wait. Not everyone is so fortunate. One of the things one tends to find in emergency rooms is old people. So many more of life’s slings and arrows become an emergency when one is frail, and old people are increasingly frail. Fall over? Emergency room. Sudden infection? Emergency room. And so on and so forth. Nurses and doctors are inordinately overworked, and there is a long backstory to this state of affairs in which the American Medical Association, generations of regulators, and hospital owners all play the villain in turn. Emergency rooms are a great place to…
Sperm Motility: Causes, Treatment, and More
Read More at Sexual Post Archive – Ben’s Natural Health In the pursuit of having a child, many people invest in fertility treatment. Infertility affects 8% to 12% of couples around the globe. Male infertility is the main or contributing cause in roughly 50% of cases, 2021 statistics show. Those with low sperm motility or immobile sperm may be unable to fertilize the egg. (1) In other words, sperm motility is a central sperm quality parameter in achieving a natural pregnancy. Thanks to IVF (in vitro fertilization) treatments, couples might still conceive with reduced sperm motility. Even in situations where there is just immobile, live sperm present. Here is a more detailed analysis of what sperm motility is, and the signs of low sperm count you should know about. What Is the Normal Sperm Motility? Motility means sperm being able…